Im currently in the process of rebuilding my 00' Silverado since i wrecked it, but im getting 22's and want a 4/6 drop. How much if any cutting will need to done to get them to work and what size tires would i need?  

you wont have any problems on a 265/35/22. but make sure you get at least a +30 mm offset on a 22x9.5 wheel for them to be able to tuck properly.